ISSN: 1305-3876
Dil: Türkçe
Hakkında: Özel sayılar şeklinde yayınlanır.
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Diagnostic And Therapeutic Approach To Leptomeningeal Carcinomatosis
Dr. Selmin ATAERGİNa
aTıbbi Onkoloji BD, GATA, ANKARA
The infiltration of the leptomeninges by malignant cells is not an umcommon complication of cancer and is called leptomeningeal carcinomatosis or carcinomatous meningitis. Leptoneningeal carcinomatosis arises from either solid tumors or haematological malignancies. In general, LC represents a devastating metastatic complication of systemic malignant disease with a dismal prognosis and increased mortality. The diagnosis is made by both lumbar puncture and radiological investigation, mainly magnetic resonance imaging. The most common associated malignancies are breast and lung cancer, melanoma, lymphomas and leukaemias. The therapeutic management of LC includes intrathecal administration of chemotherapy and radiotherapy. The treatment of LC remains controversial and no straighforward guidelines exist in the literature. The present article reviews the incidence, pathogenesis, clinical presentation, diagnosis and treatment of LC in all malignancies.Keywords: Leptomeningeal carcinomatosis, carcinomatous meningitisTurkiye Klinikleri J Surg Med Sci 2006, 2(33):83-87
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